LymphedemaV1, Main, Exploration, bibRecord, 002C60

Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice

Identifieur interne : 002C60 ( Main/Exploration ); précédent : 002C59; suivant : 002C61

Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice

Auteurs : Katrin S. Blum [Suisse] ; Sinem Karaman [Suisse] ; Steven T. Proulx [Suisse] ; Alexandra M. Ochsenbein [Suisse] ; Paola Luciani [Suisse] ; Jean-Christophe Leroux [Suisse] ; Christian Wolfrum [Suisse] ; Michael Detmar [Suisse]

Source :

PLoS ONE [ 1932-6203 ] ; 2014.

RBID : PMC:3979858

Descripteurs français

KwdFr :
- Alimentation riche en graisse (effets indésirables), Animaux, Facteur de croissance endothéliale vasculaire de type C (génétique), Facteurs temps, Modèles animaux de maladie humaine, Mâle, Obésité (anatomopathologie), Obésité (physiopathologie), Obésité (étiologie), Peau (anatomopathologie), Peau (métabolisme), Poids du corps, Souris, Souris transgéniques, Tissu adipeux (anatomopathologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiopathologie).
MESH :
- anatomopathologie : Obésité, Peau, Tissu adipeux, Vaisseaux lymphatiques.
- effets indésirables : Alimentation riche en graisse.
- génétique : Facteur de croissance endothéliale vasculaire de type C.
- métabolisme : Peau.
- physiopathologie : Obésité, Vaisseaux lymphatiques.
- étiologie : Obésité.
- Animaux, Facteurs temps, Modèles animaux de maladie humaine, Mâle, Poids du corps, Souris, Souris transgéniques.

English descriptors

KwdEn :
- Adipose Tissue (pathology), Animals, Body Weight, Diet, High-Fat (adverse effects), Disease Models, Animal, Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Male, Mice, Mice, Transgenic, Obesity (etiology), Obesity (pathology), Obesity (physiopathology), Skin (metabolism), Skin (pathology), Time Factors, Vascular Endothelial Growth Factor C (genetics).
MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C.
- adverse effects : Diet, High-Fat.
- etiology : Obesity.
- metabolism : Skin.
- pathology : Adipose Tissue, Lymphatic Vessels, Obesity, Skin.
- physiopathology : Lymphatic Vessels, Obesity.
- Animals, Body Weight, Disease Models, Animal, Male, Mice, Mice, Transgenic, Time Factors.

Abstract

Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction. However, the effects of obesity on lymphatic function have been poorly studied. We investigated if and how adipose tissue accumulation influences lymphatic function. Using a lymphatic specific tracer, we performed in vivo near-infrared (NIR) imaging to assess the function of collecting lymphatic vessels in mice fed normal chow or high-fat diet (HFD). Histological and whole mount analyses were performed to investigate the morphological changes in initial and the collecting lymphatic vessels. HFD was associated with impaired collecting lymphatic vessel function, as evidenced by reduced frequency of contractions and diminished response to mechanostimulation. Moreover, we found a significant negative correlation between collecting lymphatic vessel function and body weight. Whole mount analyses showed an enlargement of contractile collecting lymphatic vessels of the hind limb. In K14-VEGF-C mice, HFD resulted in a reduced spreading of the tracer within dermal lymphatic vessels. These findings indicate that adipose tissue expansion due to HFD leads to a functional impairment of the lymphatic vasculature, predominantly in collecting lymphatic vessels.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979858

DOI: 10.1371/journal.pone.0094713
PubMed: 24714646
PubMed Central: 3979858

Affiliations:

Suisse

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose Tissue (pathology)</term>
<term>Animals</term>
<term>Body Weight</term>
<term>Diet, High-Fat (adverse effects)</term>
<term>Disease Models, Animal</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphatic Vessels (physiopathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Obesity (etiology)</term>
<term>Obesity (pathology)</term>
<term>Obesity (physiopathology)</term>
<term>Skin (metabolism)</term>
<term>Skin (pathology)</term>
<term>Time Factors</term>
<term>Vascular Endothelial Growth Factor C (genetics)</term>
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<term>Animaux</term>
<term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term>
<term>Facteurs temps</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Obésité (anatomopathologie)</term>
<term>Obésité (physiopathologie)</term>
<term>Obésité (étiologie)</term>
<term>Peau (anatomopathologie)</term>
<term>Peau (métabolisme)</term>
<term>Poids du corps</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Tissu adipeux (anatomopathologie)</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
<term>Vaisseaux lymphatiques (physiopathologie)</term>
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<term>Tissu adipeux</term>
<term>Vaisseaux lymphatiques</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adipose Tissue</term>
<term>Lymphatic Vessels</term>
<term>Obesity</term>
<term>Skin</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Obésité</term>
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<front><div type="abstract" xml:lang="en"><p>Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction. However, the effects of obesity on lymphatic function have been poorly studied. We investigated if and how adipose tissue accumulation influences lymphatic function. Using a lymphatic specific tracer, we performed <italic>in vivo</italic>
 near-infrared (NIR) imaging to assess the function of collecting lymphatic vessels in mice fed normal chow or high-fat diet (HFD). Histological and whole mount analyses were performed to investigate the morphological changes in initial and the collecting lymphatic vessels. HFD was associated with impaired collecting lymphatic vessel function, as evidenced by reduced frequency of contractions and diminished response to mechanostimulation. Moreover, we found a significant negative correlation between collecting lymphatic vessel function and body weight. Whole mount analyses showed an enlargement of contractile collecting lymphatic vessels of the hind limb. In K14-VEGF-C mice, HFD resulted in a reduced spreading of the tracer within dermal lymphatic vessels. These findings indicate that adipose tissue expansion due to HFD leads to a functional impairment of the lymphatic vasculature, predominantly in collecting lymphatic vessels.</p>
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Serveur d'exploration sur le lymphœdème

Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice

Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice

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